David Wynford-Thomas: search on Z-Library

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1

Spontaneous de-differentiation correlates with extended lifespan in transformed thyroid epithelial cells: An epigenetic mechanism of tumour progression?

Jane A. Bond, Gro Oddweig Ness, Janet Rowson, Mircea Ivan, Denise White, David Wynford-Thomas

Journal:

International Journal of Cancer

Year:

1996

Language:

english

File:

PDF, 918 KB

english, 1996

2

10.1038/7827

Kipling, David, Wynford-Thomas, David, Jones, Chris J., Akbar, Arne, Aspinall, Richard, Bacchetti, Silvia, Blasco, Maria A., Broccoli, Dominique, DePinho, Ron A., Edwards, Dylan R., Effros, Rita B., H

Journal:

Nature Biotechnology

Year:

1999

Language:

english

File:

PDF, 88 KB

english, 1999

3

Dissociation of Telomere Dynamics from Telomerase Activity in Human Thyroid Cancer Cells

Christopher J. Jones, Anne Soley, Julia W. Skinner, Jyothi Gupta, Michele F. Haughton, Fiona S. Wyllie, M. Schlumberger, Silvia Bacchetti, David Wynford-Thomas

Journal:

Experimental Cell Research

Year:

1998

Language:

english

File:

PDF, 170 KB

english, 1998

4

Presence or absence of a G1 period in the cell cycle and growth control in a Chinese hamster cell line

D. Wynford-Thomas, G. Marin, A. LaMontagne, David M. Prescott

Journal:

Experimental Cell Research

Year:

1985

Language:

english

File:

PDF, 294 KB

english, 1985

5

Abnormalities of the EGF receptor system in human thyroid neoplasia

Nicholas R. Lemoine, Christine M. Hughes, William J. Gullick, Christopher L. Brown, David Wynford-Thomas

Journal:

International Journal of Cancer

Year:

1991

Language:

english

File:

PDF, 512 KB

english, 1991

6

RAS oncogene activation induces proliferation in normal human thyroid epithelial cells without loss of differentiation

Gire, Véronique, Wynford-Thomas, David

Journal:

Year:

2000

Language:

english

File:

PDF, 784 KB

english, 2000

7

Does telomere shortening drive selection for p53 mutation in human cancer?

Edward Bresnick, Nancy H. Colburn, Harold Moses, David Wynford-Thomas, Jane A. Bond, Fiona S. Wyllie, Christopher J. Jones

Journal:

Molecular Carcinogenesis

Year:

1995

Language:

english

File:

PDF, 545 KB

english, 1995

8

Activation of mitogen-activated protein kinase is necessary but not sufficient for proliferation of human thyroid epithelial cells induced by mutant Ras

Gire, Véronique, Marshall, Christopher J, Wynford-Thomas, David

Journal:

Year:

1999

Language:

english

File:

PDF, 1.16 MB

english, 1999

9

Direct evidence from siRNA-directed “knock down” that p16INK4a is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation

Jane Bond, Christopher Jones, Michele Haughton, Catherine DeMicco, David Kipling, David Wynford-Thomas

Journal:

Experimental Cell Research

Year:

2004

Language:

english

File:

PDF, 288 KB

english, 2004

10

Papillary Thyroid Carcinoma Oncogene (RET/PTC) Alters the Nuclear Envelope and Chromatin Structure

Andrew H. Fischer, Jane A. Bond, Panya Taysavang, O. Eugene Battles, David Wynford-Thomas

Journal:

The American Journal of Pathology

Year:

1998

Language:

english

File:

PDF, 778 KB

english, 1998

11

Mutant p53 can delay growth arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21WAF1 expression

Fiona Wyllie, Michele Haughton, Jiri Bartek, Jan Rowson, David Wynford-Thomas

Journal:

Experimental Cell Research

Year:

2003

Language:

english

File:

PDF, 214 KB

english, 2003

12

Immunohistochemical localization of cell surface receptors using a novel method permitting simple, rapid and reliable LM/EM correlation

David Wynford-Thomas, Bharat Jasani, Geoffrey R. Newman

Journal:

Journal of Molecular Histology

Year:

1986

Language:

english

File:

PDF, 3.14 MB

english, 1986

13

Investigation of putative control mechanisms for thyroid growth

David Wynford-Thomas, Bradley Michael John Stringer, Hector Ruben Harach, Edward Dillwyn Williams

Journal:

Virchows Archiv B Cell Pathology Zell-pathologie

Year:

1982

Language:

english

File:

PDF, 403 KB

english, 1982

14

The role of p53 in growth of mouse fibroblast lines

David Wynford-Thomas, Anthony LaMontagne, Guglielmo Marin, David M. Prescott

Journal:

Experimental Cell Research

Year:

1985

Language:

english

File:

PDF, 1.23 MB

english, 1985

15

DNA damage checkpoint kinase Chk2 triggers replicative senescence

Wynford-Thomas, David, Brondello, Jean-Marc, Dulic, Vjekoslav, Gire, Véronique, Roux, Pierre

Journal:

The EMBO Journal

Year:

2004

Language:

english

File:

PDF, 356 KB

english, 2004

16

Comparison of differential gene expression of hot and cold thyroid nodules with primary epithelial cell culture models by investigation of co-regulated gene sets

Markus Eszlinger, Knut Krohn, Martin Beck, David Kipling, Sarah Forbes-Robertson, Jürgen Läuter, Anke Toenjes, David Wynford-Thomas, Ralf Paschke

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2006

Language:

english

File:

PDF, 284 KB

english, 2006

17

Effect of serum growth factors and phorbol ester on growth and survival of human thyroid epithelial cells expressing mutant ras

Jane Bond, Tim Dawson, Nick Lemoine, David Wynford-Thomas

Journal:

Molecular Carcinogenesis

Year:

1992

Language:

english

File:

PDF, 776 KB

english, 1992

18

Increased apoptosis and reduced replication efficiency of the E3 region-modified dl309 adenovirus in cancer cells

Merilyn H. Hibma, Nicola C. Real, Anna Wiles, Deirdre Dobson-Le, Brett R. Dix, David Wynford-Thomas, Antony W. Braithwaite, Janice A. Royds

Journal:

Year:

2009

Language:

english

File:

PDF, 924 KB

english, 2009

19

Sporadicret-rearranged papillary carcinoma of the thyroid: a subset of slow growing, less aggressive thyroid neoplasms?

Soares, Paula, Fonseca, Elsa, Wynford-Thomas, David, Sobrinho-Simões, Manuel

Journal:

The Journal of Pathology

Year:

1998

Language:

english

File:

PDF, 267 KB

english, 1998

20

Telomerase activity and telomere length in thyroid neoplasia: biological and clinical implications

Paul Matthews, Christopher J. Jones, Julia Skinner, Michele Haughton, Catherine de Micco, David Wynford-Thomas

Journal:

The Journal of Pathology

Year:

2001

Language:

english

File:

PDF, 203 KB

english, 2001

21

Extensive allelic variation and ultrashort telomeres in senescent human cells

Baird, Duncan M., Rowson, Jan, Wynford-Thomas, David, Kipling, David

Journal:

Nature Genetics

Year:

2003

Language:

english

File:

PDF, 190 KB

english, 2003

22

Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function

Morris, Mark, Hepburn, Peter, Wynford-Thomas, David

Journal:

Year:

2002

Language:

english

File:

PDF, 462 KB

english, 2002

23

p53-Dependent growth arrest and altered p53-immunoreactivity following metabolic labelling with 32P ortho-phosphate in human fibroblasts

Bond, Jane A, Webley, Katherine, Wyllie, Fiona S, Jones, Christopher J, Craig, Ashley, Hupp, Ted, Wynford-Thomas, David

Journal:

Year:

1999

Language:

english

File:

PDF, 155 KB

english, 1999

24

Is TFIIH an activator of the p53-mediated G1/S checkpoint?

Christopher J. Jones, David Wynford-Thomas

Journal:

Trends in Genetics

Year:

1995

Language:

english

File:

PDF, 202 KB

english, 1995

25

The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2

Blaydes, Jeremy P, Wynford-Thomas, David

Journal:

Year:

1998

Language:

english

File:

PDF, 2.05 MB

english, 1998

26

Telomere erosion triggers growth arrest but not cell death in human cancer cells retaining wild-type p53: implications for antitelomerase therapy

Preto, Ana, Singhrao, Sim K, Haughton, Michele F, Kipling, David, Wynford-Thomas, David, Jones, Christopher J

Journal:

Year:

2004

Language:

english

File:

PDF, 352 KB

english, 2004

27

An immunohistochemical study of p16INK4a expression in multistep thyroid tumourigenesis

Elizabeth Ball, Jane Bond, Brigitte Franc, Catherine DeMicco, David Wynford-Thomas

Journal:

European Journal of Cancer

Year:

2007

Language:

english

File:

PDF, 424 KB

english, 2007

28

Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells

Ivan, Mircea, Bond, Jane A, Prat, Maria, Comoglio, Paolo Maria, Wynford-Thomas, David

Journal:

Year:

1997

Language:

english

File:

PDF, 768 KB

english, 1997

29

Toxicity of phorbol esters for human epithelial cells expressing a mutant ras Oncogene

Tim Dawson, Jane Bond, Neil Eccles, David Wynford-Thomas

Journal:

Molecular Carcinogenesis

Year:

1993

Language:

english

File:

PDF, 1.03 MB

english, 1993

30

PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS

Gire, Véronique, Marshall, Christopher, Wynford-Thomas, David

Journal:

Year:

2000

Language:

english

File:

PDF, 378 KB

english, 2000

31

Molecular genetic study comparing follicular variant versus classic papillary thyroid carcinomas: association of N-ras mutation in codon 61 with follicular variant

Julie Di Cristofaro, Myriam Marcy, Vasily Vasko, Frédéric Sebag, Nicolas Fakhry, David Wynford-Thomas, Catherine De Micco

Journal:

Human Pathology

Year:

2006

Language:

english

File:

PDF, 121 KB

english, 2006

32

Molecular genetics of thyroid cancer

Wynford-Thomas, David

Journal:

Trends in Endocrinology & Metabolism

Year:

1993

Language:

english

File:

PDF, 1.35 MB

english, 1993

33

The Tumour Suppressor Gene p53 as a Regulator of Proliferative Life-Span and Tumour Progression

Wynford-Thomas, David, Jones, Christopher J., Wyllie, Fiona S.

Journal:

Year:

1996

Language:

english

File:

PDF, 3.32 MB

english, 1996

34

10.1038/71630

Faragher, Richard G.A., Wyllie, Fiona S., Jones, Christopher J., Skinner, Julia W., Haughton, Michele F., Wallis, Corrin, Wynford-Thomas, David, Kipling, David

Journal:

Nature Genetics

Year:

2000

Language:

english

File:

PDF, 451 KB

english, 2000

35

Opposing effects of mutant ras oncoprotein on human fibroblast and epithelial cell proliferation: implications for models of human tumorigenesis

Skinner, Julia, Bounacer, Ali, Bond, Jane A, Haughton, Michele F, deMicco, Catherine, Wynford-Thomas, David

Journal:

Year:

2004

Language:

english

File:

PDF, 231 KB

english, 2004

36

Origin and Progression of Thyroid Epithelial Tumours: Cellular and Molecular Mechanisms

Wynford-Thomas, David

Journal:

Hormone Research

Year:

1997

Language:

english

File:

PDF, 2.38 MB

english, 1997

37

In Vitro Evidence for an Intracellular Mechanism Limiting the Thyroid Follicular Cell Growth Response to Thyrotropin

STRINGER, BRADLEY M. J., WYNFORD-THOMAS, DAVID, WILLIAMS, E. DILLWYN

Journal:

Year:

1985

Language:

english

File:

PDF, 591 KB

english, 1985

38

P53 in tumour pathology: Can we trust immunocytochemistry?

David Wynford-Thomas

Journal:

The Journal of Pathology

Year:

1992

Language:

english

File:

PDF, 188 KB

english, 1992

39

Mitogenic stimulation of normal and oncogene-transformed human thyroid epithelial cells by hepatocyte growth factor

Neil Eccles, Mircea Ivan, David Wynford-Thomas

Journal:

Molecular and Cellular Endocrinology

Year:

1996

Language:

english

File:

PDF, 530 KB

english, 1996

40

Direct growth stimulation of normal human epithelial cells by mutant p53

Fiona S. Wyllie, Nick R. Lemoine, Claire M. Barton, Tim Dawson, Jane Bond, David Wynford-Thomas

Journal:

Molecular Carcinogenesis

Year:

1993

Language:

english

File:

PDF, 559 KB

english, 1993

41

Characterisation of novel mutations in Cockayne syndrome type A and xeroderma pigmentosum group C subjects

Andrew J. Ridley, James Colley, David Wynford-Thomas, Christopher J. Jones

Journal:

Journal of Human Genetics

Year:

2005

Language:

english

File:

PDF, 202 KB

english, 2005

42

IN VIVO PHOTOINDUCTION OF METALLOTHIONEIN IN HUMAN SKIN BY ULTRAVIOLET IRRADIATION

ANSTEY, ALEXANDER, MARKS, RONALD, LONG, COLIN, NAVABI, HOSSEIN, PEARSE, ANTHONY, WYNFORD-THOMAS, DAVID, JASANI, BHARAT

Journal:

The Journal of Pathology

Year:

1996

Language:

english

File:

PDF, 573 KB

english, 1996

43

Mutant ras-induced proliferation of human thyroid epithelial cells requires three effector pathways

Bounacer, Ali, McGregor, Alex, Skinner, Julia, Bond, Jane, Poghosyan, Zara, Wynford-Thomas, David

Journal:

Year:

2004

Language:

english

File:

PDF, 188 KB

english, 2004

44

Mitotic Response to Wounding In Goitrous and Normal Rat Thyroid: Implications For Thyroid Growth Control

David Wynford-Thomas, Bradley Michael, John Stringer, Hector Ruben Harach, E. Dillwyn. Williams

Journal:

Cell Proliferation

Year:

1985

Language:

english

File:

PDF, 1.04 MB

english, 1985

45

Molecular genetics of thyroid cancer

Wynford-Thomas, David

Journal:

Current Opinion in Endocrinology & Diabetes

Year:

1995

File:

PDF, 3.87 MB

1995

46

Cytotoxic action of phorbol esters on human pancreatic cancer cells

Jane A. Bond, Andreas J. Gescher, Richard D. Verschoyle, Nicholas R. Lemoine, Rachel Errington, Marie Wiltshire, Paul J. Smith, David Wynford-Thomas

Journal:

International Journal of Cancer

Year:

2007

Language:

english

File:

PDF, 1.38 MB

english, 2007

47

Reinitiation of DNA Synthesis and Cell Division in Senescent Human Fibroblasts by Microinjection of Anti-p53 Antibodies

Gire, Veronique, Wynford-Thomas, David

Journal:

Molecular and Cellular Biology

Year:

1998

Language:

english

File:

PDF, 1.93 MB

english, 1998

48

Cellular senescence and cancer

Wynford-Thomas, David

Journal:

The Journal of Pathology

Year:

1999

Language:

english

File:

PDF, 280 KB

english, 1999

49

Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2

Blaydes, Jeremy P, Gire, Véronique, Rowson, Janet M, Wynford-Thomas, David

Journal:

Year:

1997

Language:

english

File:

PDF, 679 KB

english, 1997

50

ALTERED c-H-ras GENE IN NON-NEOPLASTIC TISSUE

Stratton, M.R., Marshall, C.J., Cooper, C.S., Nag, Abhijit, Jones, JeffreyA., Smith, RoyG., Wright, PatA., Lemoine, NickR., Dilwyn Williams, E., Wynford-Thomas, David

Journal:

Year:

1989

Language:

english

File:

PDF, 347 KB

english, 1989

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